Pyrrole Disorder

 Pyrrole Disorder is an abnormality in biochemistry resulting in the overproduction of a urinary pyrrole called OHHPL (hydroxyhemoppyrrolin-2-one).
The common clinical symptoms in patients with pyrrole disorder are anxiety (fear); poor stress tolerance; sensory hypersensitivity to light, sound, smell and/or touch; mood and emotional lability; social anxiety and/or withdrawal; poor dream recall; and commonly, explosive temper and aggression. Clinical signs are pale skin (china doll appearance), stretch marks, and white spots on the nails due to the commonly concomitant zinc deficiency. An adverse reaction to omega-3 fish oil can be an important piece of the past medical history raising clinical suspicion for the presence of pyrrole disorder.