Friday, November 9, 2012

Chapped Lips

Winter is upon us, and Mia's lips are starting to get chapped.  So what can we use with all her allergies including it being gluten and casein free??  This are the products I have found....

EOS Lip Balm- Gluten free listed on packaging.

Lip Smaker 100% Natural- There are 4 different flavors that are part of the natural line.

Carmex- Does Carmex contain gluten?- Nope, not even a speck. There is no gluten in any of our ingredients. We do not use flour in our manufacturing process, so there’s no chance of any trace of it on our conveyor belts.

Blistex- All are gluten free

Gluten Free Lotions

Dove’s Cream Oil Shea Butter, Pro-age, Cream oil body lotion and Shea butter are all gluten free. If for any reason, there is wheat, barley, rye, oats or any derivative of gluten in any of the Dove lotions, it will be clearly labeled.

Now Shea Butter is paraben free and gluten free.

The Mineral Fusion lotion line is gluten free , 100% vegetarian and free of parabens, artificial fragrances and colors.

All of the JR Watkins products are gluten free except the Aloe & Green Tea Shampoo and Conditioner

Savonneire has gluten free lotions that are also free of casein, soy, corn, colorants and fragrances.

All California Baby Lotions are gluten free, soy free, dairy free, paraben free and synthetic fragrance free. You can find them at Whole Foods, Target and Babies R Us.

Saturday, November 3, 2012

Zinc Deficiency

Zinc Deficiency

What is Zinc? 
Zinc is an essential trace metal required for cell growth & repair, immune function, gastrointestinal function, neurologic function, and many other important biochemical functions in the body. Zinc deficiency results in impaired antioxidant defenses and negative effects on many important proteins and enzymes.
There are more than 100 zinc-dependent enzymes in the body and are found in every organ system. As part of the biochemical machinery of the brain, zinc is involved in production of neurotransmitters, especially GABA. This is the catalytic role of zinc in biological systems. Zinc also serves to provide structure to proteins and cell membranes, thereby protecting them from oxidative stress and impaired function.
In addition to the catalytic and structural roles of zinc, in the form of zinc finger proteins it is involved in gene expression by acting as transcription factors, which turn on or off expression of our DNA. This influence can alter cell signaling and thereby influence release of hormones or in other cases transmission of a nerve signal along the cell.
The role of zinc in protection from oxidative stress should not be underestimated. Zinc ingestion is a potent inducer of metallothionein, a family of proteins involved in copper metabolism, zinc transport, recycling of reduced and functional form glutathione (the currency of antioxidant action in the body), protection from heavy metal toxicity, and pruning during development and learning.
What are the symptoms of Zinc Deficiency?
Because of the many effects of zinc, deficiency signs and symptoms can be quite diverse. White spots on the nails, psoriasis, acne, eczema, poor wound healing and hypogeusia (impaired sensitivity to taste) are related to the adverse effects on the dermal and immune systems. Decreased appetite, diarrhea, stunted growth, and delayed maturation are adverse effects on the endocrine and gastrointestinal system. Poor memory, irritability, and other behavioral disturbance are negative effects of zinc deficiency on brain function. Recurrent infections or increased susceptibility to unusual infections are negative effects on immune function
A high incidence of zinc deficiency is found in patients with ADHD, autism spectrum disorders, depression, schizophrenia, and bipolar disorder.
How is Zinc Deficiency Diagnosed?
Zinc deficiency is diagnosed by a finding a plasma zinc level below 100 mcg/dl. Plasma zinc is the most reliable measure of zinc adequacy and is preferred to serum zinc or intracellular zinc levels, which are less accurate.
The clinical sign of zinc deficiency is white spots on the nails.
How is Zinc Deficiency treated?
Zinc deficiency is corrected with supplementation of zinc intake. The severity of the deficiency, based on laboratory findings and clinical symptoms, determines the starting dose of zinc. The final dose is based upon ongoing measurement of plasma zinc to achieve a plasma level of 100-120 mcg/dl.
Zinc citrate is the most common form of zinc found in breast milk and is one of the preferred zinc salts to use for supplementation. Zinc picolinate is also well absorbed and is also used. Zinc arginate is potentially more absorbable in certain bowel diseases, because it is absorbed at the base and not the end of the intestinal villus (often shortened in bowel disease).  Zinc sulfate is useful dosing of zinc for dermal (skin) absorption; however, due to nausea is not well tolerated orally.  Because vitamin B6, vitamin C, vitamin E, and magnesium are often co-factors with zinc, they are also included as part of zinc deficiency treatment.
Zinc supplementation can lower copper levels; therefore, serum copper levels are also followed to ensure that supplementation of zinc has not adversely affected copper metabolism. Supplemental copper is rarely needed; however, is the solution when higher zinc doses are needed clinically, yet lead to low copper levels. In the case of concomitant abnormally high copper levels, supplementation with zinc needs to proceed gradually because zinc will induce copper elimination, which can induce irritability.
References:
Micronutrient Information Center at the Linus Pauling Institute.
Pfeiffer, CC.  Nutrition and Mental Illness.

Information from www.integrativepediatricsofohio.com

High Histamine

High Histamine

What is High Histamine Chemistry?
Histamine is the chemical commonly associated with the allergy symptoms of runny nose, itchy eyes, hives and sedation. Histamine is also a neurotransmitter and can influence mood and behavior. High histamine chemistry, as known as histadelia and originally described by Dr. Carl Pfeiffer, MD, PhD, is the constellation of clinical symptoms commonly found in persons with an elevated whole blood histamine level.
What are the symptoms of High Histamine Chemistry?
Persons with High Histamine chemistry are often motivated, attentive to detail and have good organizational abilities. When manifest normally these traits can be nurtured and thereby lead to a lifetime of success and achievement. In this case being self-motivated, achievement or goal directed and an authentic leader may be ways to describe such a person.
However, these similar traits can manifest to the extreme as perfectionism, obsessive and compulsive behaviors, competitiveness, a very high-energy/strong will and a desire for control. Depression, addictiveness, and social withdrawal are not uncommon from being at the extreme over time.
Children with more extreme symptoms can be controlling, strong-willed, and have great difficulty with authority. They can have trouble socializing with peers, preferring the company of younger children or adults. Traditional parenting is difficult and physical discipline often makes behavior worse. Parents will often describe these children as a “difficult child.”
Teens and adults with extreme symptoms can become obsessive and compulsive about a variety of things– substances (caffeine, tobacco, alcohol, drugs), food (carbs, eating disorders), electronics (especially, video and online gaming), gambling, and satisfying their high libido.
Common traditional diagnoses associated with high histamine chemistry are ADHD, ODD, depression, alcoholism, drug abuse, and a type A personality. Concomitant physical symptoms are headaches, stomach aches, muscle cramps, itching (and the tendency to pick scabs), and allergies.
Based on the clinical history of persons with high histamine chemistry, they seem to be deficient in methyl groups, the one carbon building block needed for many of the neurotransmitters in the brain. One of the most important of these neurotransmitters is serotonin. Persons with high histamine often do well with the SSRI (selective serotonin re-uptake inhibitors) class of medications. Medications with an antihistaminic effect is often well tolerated. Unfortunately, drugs with antihistaminic effects, especially cocaine, are particularly addicting for persons with high histamine.
How is High Histamine Chemistry diagnosed?
High Histamine is diagnosed by an elevated whole blood histamine. Anti-histamines or medications with antihistaminic properties can cause the test to be falsely low, so the clinical picture is an important factor in making the diagnosis.
Blood histamine represents a biological marker for response to high histamine treatment and its’ level doesn’t change with nutrient therapy, even when the person sees improvement in their clinical symptoms. Therefore, once the diagnosis is established further testing of histamine is not needed.
How is High Histamine Chemistry treated?
High histamine chemistry is treated with calcium, vitamin A, and methionine (sometimes as SAMe). Inositol, Vitamin B6, and magnesium are adjunctive nutrients that are often also needed due to the associated symptoms.
As described above, High Histamine chemistry seems to be a low serotonin state; therefore, treatments supportive of serotonin can also be helpful – 5-HTP, L-Trytophan and St. John’s Wort.
The greatest challenges to treatment of persons with high histamine are poor compliance, a tendency to stop treatment early on and a 6-12 month response time to treatment. Compliance is difficult both because of the number of supplements needs and the temperament of persons with high histamine. The later often is a struggle to maintain compliance once improvements are seen and to hang in there because of the delay until the full effect of treatment.

References:
Pfeiffer, CC. Nutrition and Mental Illness.

information from www.integrativepediatricsofohio.com

Yeast Overgrowth

The healthy gut contains both yeast and good bacteria, in balance with each other. In many Autism Spectrum Disorder (ASD) kids, however, one or the other can be out of balance. Bacteria can overgrow, or there can be a complete lack of bacteria. Also, bad bacteria can develop and take over, rather than good bacteria, causing major problems for our children.
Bacteria live in the intestinal tract, sharing space with the yeast. Antibiotic use makes yeast worse, or can start off an unhealthy reaction causing yeast overgrowth. Antibiotics kill bacteria, both good and bad, but not yeast. When using antibiotics, the bad bacteria can take over the system and yeast can grow to fill in the space left by the removal of the bacteria.
There are many strains of yeast that live in the digestive tract including candida, which appears to be the most common. There are also several different types of “bad” bacteria, including clostridia and Citrabacter F.
Both good and bad bacteria exist in the gut. Common “good” bacteria, also called beneficial bacteria, are lactobacillus acidophilus and bifidobacterium,  And don’t panic if you see it on your test but bacteria like e-coli exist in the normal gut.
Overgrowth is made possible by a dysfunctional immune system or gastrointestinal distress. A healthy immune system and regular, healthy bowel movements should keep the Candida in check. Occasionally, these complex systems “get out of check” and overgrowth of bad bugs becomes an issue.
Bacteria live in the intestinal tract, sharing space with the yeast. Antibiotic use makes yeast worse, or can start off an unhealthy reaction causing yeast overgrowth. Antibiotics kill bacteria, both good and bad, but not yeast. When using antibiotics, the bad bacteria can take over the system and yeast can grow to fill in the space left by the removal of the bacteria.
What is important to remember: Yeast live and feed on sugar. Limiting high sugar (or foods that turn into sugar in the gut) is the first and most important step. A diet high in carbs causes and feeds yeast.

What Does Yeast Overgrowth Look Like?

Yeast overgrowth manifests itself in two forms – behavior and physical.

Behavioral signs

  • Headaches
  • Inappropriate laughter
  • Sleep disturbances
  • Unexplained intermittent crying episodes
  • Belly aches
  • Constipation
  • Bed wetting
  • Gas pains
  • Fatigue
  • Depression
  • “Foggyness”
  • Inattention
  • Hyperactivity
  • Anger, aggression
  • Increased self-stimulatory behavior
  • High-pitched squealing
  • Increased sensory defensiveness
  • Climbing/jumping off things
  • Sugar cravings
  • Confusion
  • Lethargy
  • Inability to potty train, or loss of this skill
  • Self-limiting Foods
  • Plateauing in skills

Physical Signs

  • in the mouth, in the form of thrush
  • on the skin such as diaper rash or eczema
  • red ring around the anus
  • rash or cracking between the toes or joints

How Do You Test For Yeast?

According to best practices, yeast levels are best measured via a stool (poop) test.
Genova Diagnostics offers a stool test called the CDSA (Comprehensive Digestive Stool Analysis)
A test such as the CDSA tells you how much yeast, what types and amounts of yeast and (both good and bad) bacteria your child has and offers you information about which pharmaceutical and homeopathic treatments might be the most effective to treat your child’s issues.
Other labs that offer a stool analysis include Doctor’s Data and Metametrix.
Urinary Organic Acid Tests (OAT) may measure levels of “fungal metabolites” (yeast waste products) in the urine. Several labs offer this test including:

Non-Specialty Lab OAT Testing

If you only have Medicaid or prefer to use the standard lab testing:
  • OAT Test  With the exception of gut pathogen metabolites, a regular quantitative organic acid test will tell about most of the other markers on the OAT.
  • For the gut pathogen metabolites, a stool culture, O&P x3, giardia, cryptosporidium will give the bacteria and parasite parts.
  • The only bad part is that no commercial test measures beneficial flora levels. One could just use a broad spectrum probiotic, though it is better to focus more on which type of probiotic is low if there is an imbalance. The CDSA from Genova Diagnostics does all this and some insurance companies will cover it. Call your insurance company to see if they will cover the test. The Genova site offers CPT codes to use when calling about coverage.
  • The equivalent of the specialty lab testing can be achieved with 2 pieces – a standard-lab OAT and stool testing.

How Do You Treat Yeast?

There are three main ways to treat yeast overgrowth – medications, homeopathic treatments and dietary changes.
Medications are only a stop-gap measure, to be used in acute cases.
DIETARY CHANGES, i.e. REMOVING CARBOHYDRATES is the true treatment.
As long as you feed your child too many carbs, the yeast will keep coming back. Over and over and over. You must cut off it’s food supply, boost the immune system and heal the gut to stop it.

Medications (prescribed) include:

  • Nystatin
  • Ketoconosal
  • Sporonox
  • Amphoterican B
  • Flagyl (Metronidazole)
  • Nystatin
  • Diflucan (fluconazole)
  • Bactrim
  • Vancomycin
  • Neomycin
  • Lamisil
  • Nizoral
  • Vermox-generic is Mebendazole. (kills what feeds on sugar)

Homeopathic treatments include:

  • Probiotics
  • HBOT (anecdotally)
  • Colostrum
  • ThreeLac
  • Grapefruit Seed Extract (GSE)
  • Olive leaf extract
  • Oil of oregano
  • Garlic extract
  • Pau d’Arco
  • Uva ursi
  • Biotin
  • Sugar-eating enzymes like CarbDigest or No-Fenol
  • Caprylic acid
  • Berberine
  • MCT (Medium Chain Triglycerides) oil
Note: Dosing and frequency are recommended based on the individual’s age and weight. Your doctor will prescribe the treatment according to your child’s unique needs. Yeast treatments can require several treatments or reoccurring treatments to remedy the imbalance. Rarely is one yeast treatment the only requirement for keeping bacteria in balance. Dietary intervention controlling sugar and carb intake is also a crucial step in this process.

Dietary changes include:

What Is a No/Low Yeast Diet?

Yeast lives and feeds on sugar so a low/no-yeast diet would be one that limited or removed sugars, and foods that break down into simple sugars such as corn, rice, fruit. Removing juices (which are high in sugars), removing candy and all sugars is the first step. Read here for a list of sugar and carbohydrate foods that feed yeast.
The SCD-CF diet is the single most effective, and highest-rated diet, used with ASD population, because it combats not only the issue of GFCFSF but also carbs, processed foods, preservatives, colors and other toxins.
For info and recipes, see www.pecanbread.com

What are Carbs

Carbohydrates are found in sugar, fruits, vegetables, dairy and grains. They both exist in either a natural or refined form. Most carbohydrates break down into glucose (a specific type of sugar). There are two types of carbohydrates: simple carbohydrates and complex carbohydrates. Both of these feed yeast.
A diet too high in carbohydrates can upset the delicate balance of your body’s blood sugar level, resulting in fluctuations in energy and mood that leave you feeling irritated and tired.

Simple vs Complex Carbs

Simple carbohydrates include sugar, juice or soda, candy and some fruits and have little to no nutritional value and therefore should be limited. Simple carbohydrates provide short bursts of energy and activity, followed by a crash of blood sugar and energy.
Simple carbohydrates are also known as sugars. Simple carbohydrates are considered “empty calories” since there are not any vitamins or minerals in sugar. Simple carbohydrates are monosaccharide (one) and disaccharide (two) carbohydrates.
Complex carbohydrates include corn, rice, potato, nuts and oats.  Complex carbohydrates provide a slower release of energy and don’t cause the same drastic blood sugar changes. Complex carbohydrates are often referred to as starch or starchy foods.

What Should I Expect To See When Treating Yeast?

Die-off (rapid dying of gut bugs, leading to excess release of toxins) of massive quantities of yeast and bacteria can be physically hard on the body. That much dead or dying stuff flying around can wreak havoc so it’s common that we see a negative reaction, before a good reaction when starting yeast treatment. This is also called a “Herkshimer” reaction, a massive die off of pathogens. There are ways to help combat this reaction and bring your child through the process with the least bad reaction.

Things that can help lessen the negative reaction:

  • Activated Charcoal capsules
  • Alka Seltzer Gold (not regular)
  • Drinking lots of water (8 oz every 2 hours minimum)
  • High doses of Vitamin C or magnesium to get them to stool the toxins out faster
  • Gut cleanout to remove the buildup* (see below)
Typically, the die off following initial treatments can be disconcerting. Witnessing a die off reaction in the first week is typically a sign that the treatment is starting to work.  Stopping the treatment regimen prior to its completion is not recommended as it can aggravate and make the condition worse. Consult your doctor for details and to address any concerns. Not every individual on a yeast treatment protocol experience “die off” or a negative reaction.
After the typical “die off” is over, usually lasting 3-7 days, most parents report that treatment improves their children’s behavior and concentration –– kids seem more aware and less “foggy.” Anecdotal reports claim that the frequency of inappropriate noises, teeth grinding, biting, hitting, hyperactivity, and aggressive behavior decreases. The child acts less silly and shows less inappropriate laughter, just to name a few.

Does Yeast Ever Stop Being a Problem?

Parents often have to fight yeast over and over. Here are some reasons that it returns in our children.
  • Certain treatments that we use for other issues in autism, like chelation for removal of heavy metals, or anti-virals to reduce extremely high viral markers can also exacerbate yeast.
  • A common mistake parents make when starting the GFCF diet is to substitute a lot of high-sugar, high carbohydrate foods for the gluten and casein thus causing more yeast.
  • Weak immune system – since yeast overgrowth wouldn’t be possible with a healthy immune system, it’s very important to get the immune system stabilized. Leaving the immune system weak can bring back yeast in a hurry.
  • Side effect of a prescribed supplement or a drug.
  • Toxic metals, such as mercury and chemicals, such as aspartame, MSG and others can kill friendly intestinal flora, alter immune response and allow yeast to proliferate.
  • Disorders like hormonal imbalance, celiac disease or hemochromatosis.
  • Reports back from parents indicate that as the child’s overall health improves, yeast and other bacteria imbalances become less of an issue. This process takes time and a dedicated doctor to monitor and assist in this process.

Antibiotics and Other Meds

Antibiotics and other meds (oral chelation meds, for example) can cause yeast but may be needed to address other issues so probiotics and other gut/immune boosters must be given with them in order to stem the yeast flares.
You must not give antibiotics and probiotics together at the same time, you want to space them out, or the anti- will kill the pro-.
For example, if you give the antibiotic at 7am and 4pm, you want to give the probiotics at noon and bedtime (8/9 pm).
Other immune boosters should be given with antibiotics to help the body combat whatever bacteria is invading.

The Yeast Beast Reality Check – Only YOU can stop Yeast

Tips For Keeping Yeast At Bay

  • Probiotics – Rotating probiotics every 3 months to include different strains.
  • Diet – makes sure your child is not getting too much sugar or too many carbs in their diet. Limit juice consumption.
  • Enzymes – Use sugar-eating enzymes.
  • Immune boosters – products like colostrum, zinc, Vitamin C, cranberry extract, Grapefruit seed extract, and others will boost the immune system.
  • Vermox/Mebendazole – using this starves sugar-eating organisms, the standard is one pill every 10 days.
  • *Gut cleanouts – To “wipe the slate clean” every 6-12 months can be a good thing. This is a standard pediatric gut clean out protocol that has worked for us for many years:
    • Bottle of magnesium citrate (any drug or grocery store)
    • Fleet enema
    • Lots of water
    • Dulcolax: Give first according to package directions, and start hydrating with water. The next day, do enema, then give the magnesium citrate. Keep your child hydrated with water.
Article by:
Holly Bortfeld
Updated: October 30, 2012
www.tacanow.org

Lateset Autism Statistics

Latest Autism Statistics

 (www.tacanow.org)

April 17th, 2012

Autism Occurrence

  • AUTISM OCCURRENCE: One in every 88 children in the US has autism (read CDC March 2012 Study). It is estimated that approximately 1.5 million individuals in the U.S. has autism. (Note: This number and the following statistics below do NOT include: PDD, Asperger’s and other spectrum disorders.) These statistics are endorsed by the Centers for Disease Control and Prevention (CDC), American Academy of Pediatrics, and other federal agencies.
Autism Occurrence - Latest Autism Statistics

Autism Facts:

  • Autism prevalence figures are growing
  • More children will be diagnosed with autism this year than with AIDS, diabetes & cancer combined
  • Autism is the fastest-growing serious developmental disability in the U.S.
  • Autism costs the nation over $137 billion per year, a figure expected to significantly increase in the next decade
  • Autism receives approximately 5% of the government research funding of many less prevalent childhood diseases
  • Boys are four times more likely than girls to have autism
  • While there is no medical detection or known cure for autism, thousands of children have shown significant improvement resulting from early diagnosis and use of effective interventions
  • The increase in prevalence rate cannot be explained by better diagnosis alone. Some have suggested that autism is just being better diagnosed today versus years ago and that many cases of mental retardation are now being coded as autism. This would also assume that the experts diagnosing autism before did not know what they were doing. This is NOT TRUE. Autism is the only disorder dramatically on the rise while mental retardation, Down syndrome and cystic fibrosis remain relatively the same.   A January 2009 UC MIND Institute study refutes this notion.
  • While the cause of autism remains unclear, current studies show genetics and environment both play a role in the autism prevalence increase. (Genetic Heritability and Shared Environmental Factors Among Twin Pairs With Autism Joachim Hallmayer, MD; etal – Arch Gen Psychiatry. Published online July 4, 2011. doi:10.1001/archgenpsychiatry.2011.76
More recent Public School data is available for 8 year olds for the 2009-2010 school year. This graphs highlights the autism prevalence by state:
Autism Prevalence in Public Schools
Sadly, this data does not show children not in school, being homeschooled or receiving intensive services in home.

Prevalence vs. Private Funding

  • Leukemia: Affects 1 in 1,200 / Funding: $277 million
  • Muscular Dystrophy: Affects 1 in 100,000 / Funding: $162 million
  • Pediatric AIDS: Affects 1 in 300 / Funding: $394 million
  • Juvenile Diabetes: Affects 1 in 500 / Funding: $156 million
  • Autism: Affects 1 in 110 / Funding: $79 million

National Institutes of Health Funds Allocation

  • Total 2011 NIH budget: $30.5 billion
  • Of this, only $169 million goes directly to autism research. This represents 0.6% of total NIH funding

Sources:

Pyrolle Disorder

Pyrrole Disorder

What is Pyrrole Disorder?
Pyrrole Disorder is an abnormality in biochemistry resulting in the overproduction of a urinary pyrrole called OHHPL (hydroxyhemoppyrrolin-2-one). It was first discovered in the late 1950′s by a team of Canadian researchers lead by Abram Hoffer, MD when they identified a novel compound in the urine of patients with schizophrenia. OHHPL produced a lilac-colored (mauve) spot on chromatographic urine testing, and has also been referred to as Mauve Factor. It is both heat- and light-sensitive; therefore, proper collection, transport and testing precautions are required to ensure proper testing.
In the 1960s Dr. Hoffer and colleagues published clinical outcomes of schizophrenic and other mentally ill patients with high urinary pyrrole levels, showing that treatment with high dose niacinamide (the amide form of Vitamin B-3) both normalized the urinary pyrrole level and treated the clinical symptoms characteristic of pyrrole disorder (see below). In the 1970s Carl Pfeiffer, MD showed similar results with high doses of vitamin B6 and zinc, the current treatment of choice.
Vitamin B6, P5P (pyridoxal-5-phosphate), niacinamide and zinc all have important antioxidant roles. Clinical experience at the Pfeiffer Treatment Center in Warrenville, Illinois suggests that an elevated urinary pyrrole may a good biomarker for oxidative stress.
What are the symptoms of Pyrrole Disorder?
The common clinical symptoms in patients with pyrrole disorder are anxiety (fear); poor stress tolerance; sensory hypersensitivity to light, sound, smell and/or touch; mood and emotional lability; social anxiety and/or withdrawal; poor dream recall; and commonly, explosive temper and aggression. Clinical signs are pale skin (china doll appearance), stretch marks, and white spots on the nails due to the commonly concomitant zinc deficiency. An adverse reaction to omega-3 fish oil can be an important piece of the past medical history raising clinical suspicion for the presence of pyrrole disorder.
How is Pyrrole Disorder diagnosed?
Pyrrole disorder is primary a clinical diagnosis, requiring a patient with characteristic clinical symptoms and often a concomitantly elevated urinary pyrrole test result, who responds to appropriate nutrient therapy with improvement in their clinical symptoms. Patients with urinary pyrrole levels of 20 mg/dl or higher often exhibit several of the characteristic clinical symptoms. An intermediate level of 10-20 mcg/dl does not rule out pyrrole disorder because it is response to treatment that confirms the diagnosis.
How is Pyrrole Disorder Treated?
The core treatment of pyrrole disorder is vitamin B6 and/or pyridoxal-5-phosphate (the active form of vitamin B6) along with magnesium and zinc. Vitamin C, vitamin E, and niacinamide are often part of treatment due to their strong antioxidant properties, synergistic metabolic roles, and in the case of niacinamide was originally shown by Dr. Hoffer to be effective as monotherapy in treatment of clinical symptoms and elevated urinary pyrrole levels.
Unlike zinc where proper dosing of zinc is based on zinc levels, adequate dosing of vitamin B6 and P5P are based on resolution of the presenting clinical symptoms. Stress, illness, and injury all exacerbate zinc deficiency and pyrrole disorder; therefore, lifestyle changes, counseling and exercise are all necessary adjuncts to nutrient therapy. In times of severe stress or illness, additional doses of core nutrients (stress dosing) can be helpful in mitigating emergence of clinical symptoms.
Evening primrose oil is also utilized in treatment. Based on work by Bibeus et al. patients with elevated urinary pyrroles had a higher prevalence of low arachadonic acid levels on fatty acid analysis.
Clinical symptoms often return if nutritional treatment is discontinued, suggesting that once pyrrole disorder becomes clinically evident, the need for some treatment will be lifelong.

References:
McGinnis, WJ. Pyroluria: Hidden Cause of Schizophrenia, Bipolar, Depression, and Anxiety Symptoms.
McGinnis, WJ et al. Discerning the Mauve Factor, Part 1. Altern Ther Health Med. 2008 Mar-Apr; Vol 14(2): 40-50.
McGinnis, WJ et al. Discerning the Mauve Factor, Part 2. Altern Ther Health Med. 2008 may-Jun; Vol 14(3): 56-62.
Pfeiffer, CC. Nutrition and Mental Illness.

Information on www.integrativepediatricsofohio.com

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